Prof. Dr. Konstanze Plaschke

Fellow-Klasse 2014-15

Forschungsgebiete:

Experimentell: Zerebraler Funktions- und Strukturstoffwechsel; Neurotoxizität, Neurodegeneration, Neuroprotektion; Altern und altersassoziierte Erkrankungen; Stress und Kognition; Verhaltensuntersuchungen; Entwicklung von Tiermodellen der kognitiven Dysfunktion; Altersabhängige Mechanismen der Kompensation und Adaptation
Klinisch: Delirium, postoperative kognitive Dysfunktionen; kognitive Testbatterien; Monitoring bei Kindern; Biomarker: Stress und Kognition

Curriculum Vitae

Arbeitsvorhaben

Ausgewählte Publikationen:

• The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery. Plaschke K, Hauth S, Jansen C, Bruckner T, Schramm C, Karck M, Kopitz J.  J Thorac Cardiovasc Surg. 2013 Mar;145(3):805-11.
• Early postoperative delirium after open-heart cardiac surgery is associated with decreased bispectral EEG and increased cortisol and interleukin-6. Plaschke K, Fichtenkamm P, Schramm C, Hauth S, Martin E, Verch M, Karck M, Kopitz J. Intensive Care Med. 2010 Dec;36(12):2081-9.
• Role of ultrasound compared to age-related formulas for uncuffed endotracheal intubation in a pediatric population. Schramm C, Knop J, Jensen K, Plaschke K. Paediatr Anaesth. 2012 Aug;22(8):781-6
• VEGF overexpression improves mice cognitive abilities after unilateral common carotid artery occlusion. Plaschke K, Staub J, Ernst E, Marti HH. Exp Neurol. 2008 Dec;214(2):285-92.
• Comparison of the confusion assessment method for the intensive care unit (CAM-ICU) with the Intensive Care Delirium Screening Checklist (ICDSC) for delirium in critical care patients gives high agreement rate(s). Plaschke K, von Haken R, Scholz M, Engelhardt R, Brobeil A, Martin E, Weigand MA. Intensive Care Med. 2008 Mar;34(3):431-6.
• EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit. Plaschke K, Hill H, Engelhardt R, Thomas C, von Haken R, Scholz M, Kopitz J, Bardenheuer HJ, Weisbrod M, Weigand MA. Anaesthesia. 2007 Dec;62(12):1217-23.
• Chronic corticosterone-induced deterioration in rat behaviour is not paralleled by changes in hippocampal NF-kappaB-activation. Plaschke K, Feindt J, Djuric Z, Heiland S, Autschbach F, Lewicka S, Martin E, Bardenheuer HJ, Nawroth PP, Bierhaus A. Stress. 2006 Jun;9(2):97-106.
• Adenosine-induced cardiac arrest and EEG changes in patients with thoracic aorta endovascular repair. Plaschke K, Böckler D, Schumacher H, Martin E, Bardenheuer HJ. Br J Anaesth. 2006 Mar;96(3):310-6.
• Neuromodulatory effect of propentofylline on rat brain under acute and long-term hypoperfusion. Plaschke K, Grant M, Weigand MA, Züchner J, Martin E, Bardenheuer HJ. Br J Pharmacol. 2001 May;133(1):107-16.
• Transfemoral digital subtraction angiography for assessment of vertebral artery occlusion in rats. Plaschke K, Martin E, Bardenheuer HJ, Knauth M, Sartor K. Stroke. 2000 Jul;31(7):1789-90.