Prof. Dr. Thomas Kuner

Fellow-Klasse 2012-13

Forschungsgebiete:

Neurowissenschaften, Neuroanatomie, Neurophysiologie, molekulare und zelluläre Neurobiologie, Verhaltensneurobiologie, translationale neuropsychiatrische Forschung; Themen: Synaptische Transmission, Struktur und Funktion des Nervensystems, Sinnessysteme (Olfaktion, Audition, Somatosensibilität und Schmerz), hochauflösende bildgebende Verfahren.

Curriculum Vitae

Arbeitsvorhaben

Ausgewählte Publikationen:

• Abraham, N.M., Egger, V., Shimshek, D.R., Renden, R., Fukunaga,. I., Sprengel, R., Seeburg, P.H., Klugmann, M., Margrie, T.W., Schaefer, A.T.#, Kuner, T. # (2010). Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice. Neuron 65, 399-411.
• Kuner, T. #, Wollmuth, L. P., Karlin, A., Seeburg, P. H., and Sakmann, B. (1996). Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines. Neuron 17, 343-352.
• Beck, C., Wollmuth, L. P., Seeburg, P. H., Sakmann, B., and Kuner, T.# (1999). NMDA receptor channel segments forming the extracellular vestibule inferred from the accessbility of substituted cysteines. Neuron 22, 559-570.
• Kuner, T. and Augustine, G. J. # (2000). A genetically encoded ratiometric indicator for chloride: capturing chloride transients in hippocampal neurons. Neuron 27, 447-459.
• Dübel, J., Haverkamp, S., Schleich, W., Augustine, G.J., Feng, G., Kuner, T. #, Euler, T.# (2006). Two-photon imaging reveals somato-dendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon. Neuron 49, 81-94.
• Abraham, N.M., Spors, H., Carleton, A., Margrie, T., Kuner, T., Schaefer, A.T. # (2004). Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice. Neuron 44, 865-876.
• Kuner, T. #, Li, Y., Gee, K. R., Bonewald, L. F., Augustine, G. J. (2008). Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release. PNAS 108, 347-352.
• Wimmer, V.C., Nevian, T., and Kuner, T.# (2004). Targeted in vivo expression of proteins in the calyx of Held. Pflugers Archiv/European Journal of Physiology 449, 319-333.
• Groh, A., de Kock, C.P.J., Wimmer, V.C., Sakmann, B., Kuner, T. # (2008). Driver or coincidence detector: modal switch of a corticothalamic giant synapse controlled by spontaneous activity and short-term depression. J Neurosci. 28, 9652-9663.
• Kuner, T. #, and Schoepfer, R. (1996). Multiple Structural Elements Determine Subunit-Specificity of Mg2+ Block in NMDA Receptor Channels. J. Neuroscience 16, 3549-3558.