Prof. Dr. Thomas Holstein

Fellow-Klasse 2011-12
Fellow-Klasse 2013-14

Forschungsgebiete:

Evolutionsbiologie, Zell- und Entwicklungsbiologie vergleichende Genomik, Ursprung der Metazoa, Stammzellen; Signalmoleküle (Wnt, Bmp, Dickkopf Proteine), Regeneration; extrusive Organelles (Nematocyten), live cell imaging, hochauflösende Mikroskopie

Curriculum Vitae

Arbeitsvorhaben


 

Ausgewählte Publikationen:

• Holstein TW (2012). The evolution of the Wnt pathway. Cold Spring Harb Perspect Biol. 4: a007922 Chapman JA, Kirkness EF, Simakov O et al. (2010). The dynamic genome of Hydra. Nature 464, 592-6.
• Chapman JA, Kirkness EF, Simakov O et al. (2010). The dynamic genome of Hydra. Nature 464, 592-96.
• Watanabe H, Hoang VT, Mättner R, Holstein TW (2009). Immortality and the base of multicellular life: Lessons from cnidarian stem cells. Semin Cell Dev Biol 20, 1114-25.
• David CN, Ozbek S, Adamczyk P, Meier S, Pauly B, Chapman J, Hwang JS, Gojobori T, Holstein TW (2008). Evolution of complex structures: minicollagens shape the cnidarian nematocyst. Trends Genet 24, 431-38.
• Rentzsch F, Guder C, Vocke D, Hobmayer B, and Holstein TW (2007). An ancient chordinlike gene in organizer formation of Hydra. Proc Natl Acad Sci USA 104, 3249-54.
• Kusserow A, Pang K, Sturm C, Hrouda M, Lentfer J, Schmidt HA, Technau U, von Haeseler A, Hobmayer B, Martindale MQ, and Holstein TW (2005) Unexpected complexity of the Wnt gene family in a sea anemone. Cover story. Nature 433, 156-60.
• Engel U, Pertz O, Fauser C, Engel J, David CN, Holstein TW (2001). A switch in disulfide linkage during minicollagen  assembly in Hydra nematocysts. EMBO J. 20, 3063-73.
• Technau U, Cramer von Laue C, Rentzsch F, Luft S, Hobmayer B, Bode HR, Holstein TW (2000). Parameters of  self-organization in Hydra aggregates. Proc Natl Acad Sci USA 97, 12127-31.
• Hobmayer B, Rentzsch F, Kuhn K, Happel CM, von Laue CC, Snyder P, Rothbächer U, Holstein TW (2000). WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra. Nature 407, 186-9.
• Holstein TW, Benoit M, Herder GV, David CN, Wanner G, Gaub HE (1994). Fibrous minicollagens in hydra nematocysts. Science 265, 402-4.
• Holstein T, Tardent P (1984). An ultrahigh-speed analysis of exocytosis: nematocyst discharge. Science 223, 830-3.